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Superdrug Slenderplan Meal Replacement Shakes Review
Instruct patients to immediately report if they experience any of the above signs or symptoms. However, several times I had forgot to take it and did not want to eat at all, almost all day. My fasting sugar is and pp after taking medicine in the morning with break fast. No such contact has been made since. Avoid administration of rivaroxaban distal to the stomach which can result in reduced absorption and related drug exposure.

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Days 20 mg per tablet, once daily 9 tablets. Atrial Fibrillation diltiazem , propranolol , digoxin , sotalol , flecainide , rivaroxaban , More By clicking Subscribe, I agree to the Drugs. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

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To view content sources and attributions, please refer to our editorial policy. We comply with the HONcode standard for trustworthy health information - verify here. Premature discontinuation of Xarelto increases the risk of thrombotic events Premature discontinuation of any oral anticoagulant, including Xarelto, increases the risk of thrombotic events. These events occurred during treatment or within 2 days of stopping treatment. Fatal bleeding is adjudicated death with the primary cause of death from bleeding.

Although a patient may have had 2 or more events, the patient is counted only once in a category. Xarelto 10 mg once daily or aspirin mg once daily. Major bleeding event 5 0. Patients may have more than one event.

Data are shown for all randomized patients followed to site notification that the study would end. If the same patient had several events, the patient may have been counted for several components. The individual component of the primary endpoint represents the first occurrence of the event.

Primary Composite Endpoint 13 1. NDC day starter blister pack containing 51 tablets: Medication Guide has been approved by the U.

Food and Drug Administration Revised: For people taking Xarelto for atrial fibrillation: People with atrial fibrillation an irregular heart beat are at an increased risk of forming a blood clot in the heart, which can travel to the brain, causing a stroke, or to other parts of the body.

Xarelto lowers your chance of having a stroke by helping to prevent clots from forming. If you stop taking Xarelto, you may have increased risk of forming a clot in your blood.

Do not stop taking Xarelto without talking to the doctor who prescribes it for you. Stopping Xarelto increases your risk of having a stroke. If you have to stop taking Xarelto, your doctor may prescribe another blood thinner medicine to prevent a blood clot from forming. Xarelto can cause bleeding which can be serious, and rarely may lead to death.

This is because Xarelto is a blood thinner medicine anticoagulant that reduces blood clotting. While you take Xarelto you are likely to bruise more easily and it may take longer for bleeding to stop.

You may have a higher risk of bleeding if you take Xarelto and take other medicines that increase your risk of bleeding, including: Ask your doctor or pharmacist if you are not sure if your medicine is one listed above.

Call your doctor or get medical help right away if you develop any of these signs or symptoms of bleeding: People who take a blood thinner medicine anticoagulant like Xarelto, and have medicine injected into their spinal and epidural area, or have a spinal puncture have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move paralysis. Your risk of developing a spinal or epidural blood clot is higher if: Tell your doctor right away if you have back pain, tingling, numbness, muscle weakness especially in your legs and feet , loss of control of the bowels or bladder incontinence.

Xarelto is not for people with artificial heart valves. Xarelto is a prescription medicine used to: With atrial fibrillation, part of the heart does not beat the way it should. This can lead to the formation of blood clots, which can travel to the brain, causing a stroke, or to other parts of the body.

Do not take Xarelto if you: Talk to your doctor before taking Xarelto if you currently have unusual bleeding. See the end of this leaflet for a complete list of ingredients in Xarelto.

Before taking Xarelto, tell your doctor about all of your medical conditions, including if you: It is not known if Xarelto will harm your unborn baby. Tell your doctor right away if you become pregnant during treatment with Xarelto.

Taking Xarelto while you are pregnant may increase the risk of bleeding in you or in your unborn baby. If you take Xarelto during pregnancy tell your doctor right away if you have any signs or symptoms of bleeding or blood loss.

See " What is the most important information I should know about Xarelto? Xarelto may pass into your breast milk. You and your doctor should decide if you will take Xarelto or breastfeed. Tell all of your doctors and dentists that you are taking Xarelto. They should talk to the doctor who prescribed Xarelto for you before you have any surgery, medical or dental procedure.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some of your other medicines may affect the way Xarelto works. Certain medicines may increase your risk of bleeding. Take Xarelto exactly as prescribed by your doctor.

Do not change your dose or stop taking Xarelto unless your doctor tells you to. Your doctor may change your dose if needed. If you take Xarelto for: Take Xarelto 1 time a day with your evening meal. If you miss a dose of Xarelto, take it as soon as you remember on the same day. Take your next dose at your regularly scheduled time. Take Xarelto 1 or 2 times a day as prescribed by your doctor. For the 15 mg and 20 mg doses , Xarelto should be taken with food.

For the 10 mg dose , Xarelto may be taken with or without food. Take your Xarelto doses at the same times each day. If you miss a dose: Take Xarelto as soon as you remember on the same day. You may take 2 doses at the same time to make up for the missed dose.

Take Xarelto 1 time a day with or without food. If you have difficulty swallowing the Xarelto tablet whole, talk to your doctor about other ways to take Xarelto.

Your doctor will decide how long you should take Xarelto. Your doctor may stop Xarelto for a short time before any surgery, medical or dental procedure. Your doctor will tell you when to start taking Xarelto again after your surgery or procedure. Do not run out of Xarelto. Refill your prescription of Xarelto before you run out.

When leaving the hospital following a hip or knee replacement, be sure that you will have Xarelto available to avoid missing any doses. If you take too much Xarelto, go to the nearest hospital emergency room or call your doctor right away. What are the possible side effects of Xarelto?

How should I store Xarelto? Keep Xarelto and all medicines out of the reach of children. General information about the safe and effective use of Xarelto. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Xarelto for a condition for which it was not prescribed. Do not give Xarelto to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or doctor for information about Xarelto that is written for health professionals.

What are the ingredients in Xarelto? Finished Product Manufactured by: Titusville, NJ Licensed from: For more information call or go to www.

Print this page Add to My Med List. Xarelto Rating User Reviews 6. Subscribe to free Drugs. FDA alerts for all medications. Treatment of DVT 2. Bleeding into a critical organ. Bleeding that required re-operation. General disorders and administration site conditions. Musculoskeletal and connective tissue disorders. Skin and subcutaneous tissue disorders. Pretty much just a well-branded protein shake — the formula is not very innovative There are no fat burning ingredients inside the formula There are no appetite suppressing ingredients inside the formula — users may find themselves constantly hungry while sticking to the shake-only diet Users may find any weight loss quickly returns once they stop using the shakes to replace their three daily meals No money-back guarantee.

Most people who want to lose weight do not need to follow a very low calorie diet. We have found the following ingredient information from the Superdrug website: We have compiled the following list of potential side effects based on the ingredients used within the formula: What does Superdrug Meal Replacement Shakes claim to do? We have found the following Superdrug Meal Replacement Shakes review testimonials: You can buy this product on the Superdrug website as well as in most stores.

Health Editor at DietProbe. Kathryn is a Ph. D Health Editor here at DietProbe. She specializes in diabetes and weight control research and in her spare time she's a professional cat lady and wine connoisseur! The doctors operate and discover that the liver is in an even worse state than they had feared. The organ contains swellings that are filled with blood. The doctors also found a swelling with a diameter of 23 cm. The doctors decide to amputate part of the liver. After the operation the bodybuilder recovers and is allowed home.

When the doctors make another scan three months later they see that the swellings in the remaining part of the liver have shrunk by 40 percent, Picture B above. After three years the bodybuilder returns to the doctors. Six weeks previously he had treated himself to injections of a nandrolone derivative.

When the doctors make another scan — the picture above on the right — they see that his liver is in a bad way again. The swellings have started to grow again, and the liver has a protuberance that has started to bleed. The doctors discuss briefly whether they should give the guy a new liver, but reject the idea. It would be a waste: Alcoholics are not given a new liver either. So they just stop the bleeding and send the bodybuilder home again.

Thinking about it, we find it difficult to believe that the bodybuilder was only using deca and androstenedione. True, a number of cases have been published of bodybuilders who, as the result of a mild course of deca, developed a blood clot the size of a brick in their stomach, or became psychotic after one single deca injection.

Moreover, neither androstenedione nor nandrolone is harmful to the liver. Laboratory research on liver cells has shown this. And, by the time the doctors were seeing their patient, George Bush had already outlawed androstenedione. Although androstenedione is still on the market, bodybuilders hardly ever use it. In countries like the US there are much more effective legal anabolic steroids available.

But among these, there are a number of substances that are notoriously bad for the liver. The most dangerous is Superdrol, an anabolic that was developed at the end of the fifties by Syntex.

Doctors have recorded damaged livers and destroyed kidneys in users of Superdrol more than once. This is what makes us suspect that the bodybuilder in this case study used stronger stuff than androstenedione and deca. Bodybuilders are often not entirely honest about what they have been using when they visit a doctor about medical problems.

Even when being honest could have saved their life. Bodybuilder gets jaundice from creatine and protein supplements. A healthy man of 27, a fanatical bodybuilder, developed liver damage and jaundice after using sports supplements containing creatine and whey protein.

The man in the case study had no pain and did not feel unwell, but because he showed signs of jaundice he went to hospital. There the doctors discovered that his blood contained high levels of bilirubin, a substance that should have been removed by the liver.

The first substance can be an indication of liver malfunction. The second is a waste product of creatine. In people with jaundice, the skin and whites of the eyes turn yellow [see pic below], but this is not necessarily cause for alarm.

Bilirubin is not a dangerous substance, and may even be an endogenous antioxidant. But jaundice is a sign that something is wrong with the liver, and it therefore needs to be taken seriously.

The ducts that should have been doing so were blocked. The scientific term for this is cholestasis. The bodybuilder had been taking creatine for nine months and whey protein for one month. The doctors thought that this might be responsible for his condition.

When the man stopped taking the supplements, his liver returned to normal and the jaundice disappeared. If doctors come across healthy athletes with an abnormal liver, the researchers write, then they should ask whether the athletes are using potentially 'dangerous' supplements like whey protein and creatine.

We agree with the opinion of a blogger — who by the way also works at Gaspari Nutrition — at bodybuilding. But these reports are probably the result of silent use of forbidden substances — and in high quantities.

For example, there was the bodybuilder who said he had developed gyno from using Tribulus terrestris supplements. A preparation made by Natterman, which supposedly protects the liver and which chemical athletes are using more and more often: Greek researchers refer to it in their study as compound N. The researchers, at Thessaly University, set up an experiment to determine whether compound N really works. After a bit of surfing we worked out that Compound N is Essentiale forte.

A packet contains a couple of dozen capsules, each of which contains mg of polyene phosphatidylcholine. This is choline-phosphoric acid with two unsaturated fatty acids attached, usually linoleic acid.

It probably resembles the phosphatidylcholine found in soya. In addition, each capsule contains 6 mg of vitamin B1, 6 mg of vitamin B2, 6 mg of vitamin B6, 6 mcg of vitamin B12, 30 mg of nicotinamide and 6 mg of vitamin E. The Greeks, who by the way have also done research on the psychological effects of anabolic steroids, did an experiment with three hundred and twenty athletes.

Half of them, one hundred and sixty athletes, used steroids. Of these chemical athletes, the researchers gave forty Essentiale forte: All of the chemical athletes took steroids and the researchers monitored them for eight weeks.

The list below gives you an idea of what the Greek bodybuilders were using. Yes, the list puzzled us too.

And where are the 'new' designer steroids? Surely athletes in Greece use products like 1-Test and Madol too? The more enzymes in the blood, the harder a time the liver is having. The figure below shows what happened to the liver enzyme concentrations.

They suspect that the mixture strengthens the membranes of the liver cells. The livers of steroids users have to work hard to break down all the extra substances they are subjected to.

The liver gets fattier because the liver cells are no longer burning fat well [beta-oxidation — Ed. The supplement helps the liver cells to perform these functions.

Reading between the lines you can also see that the Greeks had trouble getting their study published. More damaged livers from superdrol and madol. Liver specialists at the Henry Ford Hospital in Detroit have reported another three cases of bodybuilders who developed liver damage as a result of using designer supplements. The Superdrol user was He was nauseous, had stopped eating, had jaundice and itched all over.

When the symptoms had got worse after two weeks, the doctors gave him prednisone. The anti-inflammatory worked and after another six weeks, he'd made a pretty good recovery. Superdrol is a steroid whose structure and synthesis resemble those of oxymetholone.

It was also developed and tested in the late fifties by the makers of oxymetholone, the American pharmaceutical company Syntex. Although superdrol [see structural formula below] looked like a promising anabolic steroid in animal tests, in subsequent tests potential side effects showed up. The effects of this move are clearly seen in the medical journals.

In doctors in Phoenix, Arizona published an article on the case of bodybuilder who became fatally ill after using superdrol.

What patient 2 used was not clear, but it contained at least DHEA. Of the three men referred to in the study, number 2 got off the most lightly. He recovered spontaneously a couple of weeks after he had stopped using the supplement.

Patient 3 used M-Test 2, a designer supplement containing the steroid madol. Madol was also developed by Syntex, a manufacturer that carried out promising animal tests on it in the sixties. Not much is known about the side-effects of madol. It is not carcinogenic, say German researchers. But they did discover that it enlarged the heart muscle in animal tests.

The enlargement itself was not dangerous, but the researchers were not entirely convinced. In the bodybuilding circuit however there are few stories around of users who have developed liver problems as a result of using madol. The sick madol user had to be given prednisone in the end, after which he recovered. The doctors did not test the preparation the patient had used. And we wonder quite honestly if it only contained madol.

According to the study, the bodybuilder became ill after he had taken 57 capsules over a period of a few weeks. That would be impossible with. The Canadian government has issued warnings about these. Maybe something went wrong during the production of M-Test 2. Or perhaps the doctors got it wrong that Patient 3 used the BMF product. The doctors also read a couple of articles written by colleagues and summarized the information they found.

This resulted in the table you see here below. Liver specialists should get extra training on designer supplements that contain oral anabolic steroids, the article concludes. Published online November Abstract We report three cases of patients with acute liver injury induced by weight-loss herbal supplements. One patient took Hydroxycut while the other two took Herbalife supplements. Liver biopsies for all patients demonstrated findings consistent with drug-induced acute liver injury.

To our knowledge, we are the first institute to report acute liver injury from both of these two types of weight-loss herbal supplements together as a case series. The series emphasizes the importance of taking a cautious approach when consuming herbal supplements for the purpose of weight loss.

Hydroxycut, Herbalife, Hepatotoxicity, Herbal, Weight-loss. We have seen a significant increase in the popularity and usage of over the counter herbal supplements over the past few years[ 1 ]. Unfortunately, the majority of these herbal supplements are not regulated by drug administrations worldwide. Many herbal supplements contain compounds that carry potentially severe side effects including hepatotoxicity.

We report three cases of acute liver injury induced by weight-loss herbal supplements. Hydroxycut is a popular dietary supplement consisting of a variety of herbal mixtures that claims to enhance the weight loss process[ 2 ]. Acute liver injury associated with Hydroxycut use has been previously reported, but only one case had liver biopsy data showing cholestasis and portal inflammation[ 3 - 6 ].

Similarly, Herbalife weight-loss dietary products are popular supplements consisting of a variety of herbal mixtures that claim to facilitate weight reduction[ 7 ]. Cases of acute liver injury after consumption of Herbalife products have been previously reported, with two patients developing fulminant liver failure requiring liver transplantation.

The first patient survived while the second died[ 8 - 11 ]. In all of our cases, we were able to demonstrate drug-induced acute liver injury on liver biopsy specimens. Case 1 A year-old woman presented to our hospital complaining of 2-wk history of fatigue, jaundice, and nausea. She denied any prior medical or surgical conditions, family history of liver disease, and acetaminophen or prescription medication use.

She further denied history of blood transfusion, tattoo, alcohol use, or recreational drug use. She had been taking Hydroxycut for one year to enhance her weight loss. She had been taking the recommended dose of 2 tablets twice a day. The patient was afebrile with normal hemodynamics upon presentation. Her physical examination was remarkable for generalized jaundice, scleral icterus, and mild upper quadrant tenderness to palpation without rebound or guarding.

Given these findings, patient was admitted to the hospital for a higher level of care. Serum acetaminophen and urine toxicity screens were negative. Serum ceruloplasmin, ferritin, iron studies, and immunoglobulins were all within the normal range. Right upper quadrant ultrasound showed diffuse echogenicity of the liver. Liver biopsy showed extensive patchy areas of multilobular necrosis with only bile ducts remaining, extensive ductal metaplasia, severe lymphocytic and macrophages infiltration of portal tracts and lobular parenchyma and patchy plasma cell infiltrates.

She did not develop evidence of hypoglycemia or portal-systemic encephalopathy. Her jaundice and scleral icterus resolved over the following 2-wk. Her liver tests gradually improved within the following few months. Case 2 A year-old woman presented to our hospital with a 1-mo history of diffuse abdominal pain, mild nausea, and painless jaundice.

She denied any past medical or surgical history, family history of liver disease, or any alcohol or illicit substance abuse. She admitted that she had been taking Herbalife dietary supplements for the past 3-mo in an attempt to lose weight. The patient was afebrile with normal vital signs on presentation. Her physical exam was noticeable for bilateral scleral icterus and generalized jaundice. Her abdominal exam revealed a non-tender, non-distended abdomen with no stigmata of liver disease.

All other laboratory values, including amylase, lipase, and INR, were within normal limits. Given these lab abnormalities, the patient was admitted to the hospital for further work-up. Serum ceruloplasmin, ferritin, iron studies, and immunoglobulins were all within normal range. A computerized tomography CT scan of the abdomen and pelvis with intravenous IV contrast showed multiple low-density lesions in the liver measuring up to 8-mm.

However, her liver biopsy specimens also showed evidence of bridging fibrosis, which suggest some degree of chronic liver disease but with drug-induced injury in addition. Liver biopsy was performed and showed periportal bridging fibrosis, ductal metaplasia, cholestasis, moderate intralobular lymphocytic infiltration, and troxis necrosis and apoptosis consistent with drug-induced hepatitis on top chronic liver disease.

The patient was treated supportively with fluids and nutrition. The only laboratory value to increase was the patient's serum TB, which was at The patient did not develop encephalopathy, hypoglycemia, or any other complications.

The patient was followed for several months, throughout which her symptoms continued to improve. At her 2-mo follow-up, the patient's icterus and jaundice had resolved completely.

Case 3 A year-old previously healthy woman presented with a 3-wk history of painless jaundice and pruritus. She denied any family history of liver disease, or any alcohol or illicit substance abuse. She had not been taking any new prescribed medications.

On further questioning about over-the-counter supplements she divulged a 4-mo history of consuming various Herbalife weight loss products in the form of shakes, teas and pills.

On general inspection she had scleral icterus and jaundice, with evidence of excoriations. A 2-cm palpable liver edge could be appreciated, that was tender to touch. There were no other signs of chronic liver disease. An ultrasound showed borderline hepatomegaly of cm.

A liver biopsy revealed acute hepatitis characterized by hepatocellular injury, with periportal fibrosis, cholestasis, ductal metaplasia and diffuse intralobular and periportal troxis necrosis consistent with a drug-induced etiology.

Acute liver injury induced by over the counter weight-loss herbal supplement Hydroxycut and Herbalife products have been reported previously[ 3 - 6 , 8 - 11 ]. These case reports were limited by the fact that liver biopsies were performed in only a few patients, confirming clinical suspicions histologically.

In terms of our patients, all three had liver biopsy performed and all showed some common morphological features including diffuse lymphocytic infiltration of sinusoids and portal tracts, ductal metaplasia and toxic necrosis. Some variations of morphological features could be explained by predominance of intrinsic or idiosyncratic mechanisms of hepatic injury, individual patient response to the affecting drug and duration of injury.

No hyaline globules were identified in any of the three cases. The absence of histological findings and the fact that our patients had no history of chronic obstructive pulmonary disease excluded diagnosis of alphaantitripsin deficiency in all three cases. Prussian blue and copper stains did not reveal excessive iron or copper depositions in the hepatocytes and Kupffer cells. Only one previous case of Hydroxycut-induced acute liver injury had reported findings on liver biopsy.

Although the most likely explanation for the mechanism of liver injury caused by these herbal products is idiosyncratic reaction, one of the ingredients in Hydroxycut, green tea extract Camellia sinensis , has been linked with acute liver injury in other over the counter weight-loss herbal supplements[ 12 - 20 ]. In fact, the weight-loss herbal supplement Exolise Arkophama, Carros, France , which also contained C.

Furthermore, several cases of hepatotoxicity were associated with another herbal weight-loss supplement, Cuur Scandinavian Clinical Nutrition, Sweden , which also contains the ethanolic dry extract of green tea C.

Rechallenging patients with the same product led to hepatotoxicity, confirming the role of C. However, there have been cases of liver failure caused by green tea extract C. The liver biopsy obtained in our patient who took Hydroxycut showed multi-lobular necrosis consistent with acute toxic necrosis and fulminant hepatitis.

These findings are similar to the findings in patients with liver injury associated with green tea extract C. The exact mechanism of hepatotoxicity induced by Hydroxycut is unknown. However, as this product contains green tea extract C. Prior investigation into the mechanism of hepatotoxicity by green tea extract was inconclusive[ 21 ].

Others have hypothesized that a possible allergic reaction to the green tea extract, contamination during the production of the extract or a metabolic idiosyncrasy are possible mechanisms of liver injury in these patients[ 16 ]. Both of our patients took several Herbalife weight-loss herbal products concurrently, similar to most of the previously reported cases of hepatotoxicity due to Herbalife products[ 8 - 11 ].

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